| Links Between Peyronie’s Disease and Dupuytren’s Disease | | Published by: admin 2008-08-20 |
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According to a report published in 1995 by the National Institutes of Health, Peyronie’s disease occurs in about 1% of men. About 30 percent of men with Peyronie’s disease develop fibrosis (hardened cells) in other elastic tissues of the body, such as on the hand or foot, a condition known as Dupuytren’s contracture of the hand. According to some experts, men that have Dupuytren’s contracture may have a higher genetic predisposition to develop Peyronie’s disease.
Peyronie’s disease or Induratio Penis Plastica or Morbus Peyronie, is charactherized by bent penis due to collagen accumulation and tissue contraction, a condition similar to e.g. Dupuytren’s disease. Dupuytren’s disease or Morbus Dupuytren is a fibrotic tissue disorder or wound healing disorder that affects the hands. It is a non-cancerous thickening of the fascia that is characterized by the presence of excess collagen or fibrotic tissue that forms firm lumps in the palm or fingers. Dupuytren’s contracture, or rather Dupuytren’s disease, typically starts on the hand’s palm with a little nodule or several nodules that can be felt (palpated) and are initially not very hard. The disease is typically named Dupuytren’s contracture; the term Dupuytren’s disease includes the initial stage of the disease without contracture. There are some experts who believe that to get Peyronie’s disease and probably to get Dupuytren’s contracture a man needs to have a certain genetic make-up and this may be the link between the two conditions.
In Peyronie’s disease, mini inflammation can be the cause of penis lump, while in Dupuytren’s disease, the chronic inflammation is located in the flexible area of the skin in the vicinity of the base joints of the fingers, typically the fourth and fifth fingers. Peyronie’s disease can appear in short time while Dupuytren’s disease typically develops over 5 - 10 years. Dupuytren’s disease is most common in Caucasian populations having a global prevalence of 3-6% with the highest prevalence being in Scandinavia.
The treatment for Peyronie’s disease is seemed partially similar to Dupuytren’s disease. Shock waves seem to work for Peyronie’s disease but not for Dupuytren’s disease, while radiation therapy is in some countries applied for Peyronie’s disease as well as Dupuytren’s disease. Verapamil treatment seems works for both diseases.
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